Vacuolar transport

Across TCGA patient cohorts, RNA activity of the Vacuolar transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S835, CEP170_S1239, and PPP4R3A_S117, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vacuolar transport activity versus TNS2_S835 in BRCA (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNS2_S835 →	+0.425	+0.179	.006	<.001	3	2
OV	CEP170_S1239 →	+0.977	+0.290	<.001	<.001	3	2
COAD	PPP4R3A_S117 →	+0.952	+0.342	<.001	.002	2	3
BRCA	RCL1 →	-0.344	-0.164	.002	<.001	3	2
BRCA	ATN1_S661 →	-0.469	-0.214	.001	<.001	3	2
COAD	RNF139_T663 →	-0.552	-0.164	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007034 vs TNS2_S835 — BRCA

Explore this scatter interactively →