Vacuolar transport

Across TCGA cell cohorts, RNA activity of the Vacuolar transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPAA1, LRRC58, and TIMM10B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPAA1 grouped by Vacuolar transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPAA1 →	+0.709	+0.209	<.001	.001	3	5
BONE	LRRC58 →	-0.827	-0.299	.002	.005	3	4
KIDNEY	TIMM10B →	+0.522	+0.221	<.001	<.001	3	4
KIDNEY	ZNF808 →	+1.106	+0.233	<.001	<.001	3	4
BREAST	PTK2 →	+0.806	+0.120	<.001	.006	3	4
LUNG_NSCLC_LUAD	TMEM182 →	+0.675	+0.177	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPAA1 by Vacuolar transport activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →