Vacuole organization

Across TCGA patient cohorts, RNA activity of the Vacuole organization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S432, MAP1B, and YME1L1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vacuole organization activity versus SEPTIN4_S432 in GBM (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN4_S432 →	+0.952	+0.042	<.001	<.001	3	8
PDAC	MAP1B →	+0.289	+0.019	<.001	<.001	3	8
BRCA	YME1L1 →	-0.266	-0.019	<.001	<.001	3	8
BRCA	RPL10A →	-0.238	-0.029	<.001	<.001	3	7
GBM	RPL5 →	-0.212	-0.034	.002	.003	1	9
GBM	CLPX →	-0.331	-0.046	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007033 vs SEPTIN4_S432 — GBM

Explore this scatter interactively →