Vacuole organization

Across TCGA cell cohorts, RNA activity of the Vacuole organization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUFIP2, EPHA2, and HSF2BP, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUFIP2 grouped by Vacuole organization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NUFIP2 →	+0.879	+0.128	.002	.009	3	3
OESOPHAGUS	EPHA2 →	+1.577	+0.169	.005	.005	3	3
OVARY	HSF2BP →	-0.523	-0.829	.004	<.001	3	3
LIVER	DDX41 →	+0.590	+0.191	.005	.003	3	3
PANCREAS	GTSE1 →	+0.903	+0.232	.006	<.001	2	3
LUNG_SCLC	C21orf58 →	+0.847	+0.156	.008	.006	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUFIP2 by Vacuole organization activity — OESOPHAGUS

Explore this box plot interactively →