Vacuole organization

Across TCGA cell cohorts, RNA activity of the Vacuole organization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST6GALNAC4, C16orf72, and SSB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vacuole organization activity versus ST6GALNAC4 in BREAST (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ST6GALNAC4 →	-1.482	-0.155	.005	.007	3	5
LIVER	C16orf72 →	+0.542	+0.155	.006	.004	3	5
STOMACH	SSB →	-0.585	-0.146	.007	.002	3	5
LUNG_SCLC	PIP4P1 →	+0.778	+0.184	.006	.005	3	5
PANCREAS	CTCF →	+0.732	+0.147	.003	.008	3	4
BREAST	GOLPH3 →	+0.517	+0.159	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007033 vs ST6GALNAC4 — BREAST

Explore this scatter interactively →