Endosome organization

Across TCGA patient cohorts, RNA activity of the Endosome organization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, SORBS1, and RPL10A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosome organization activity versus RPL5 in BRCA (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL5 →	-0.188	-0.023	.003	.009	3	7
COAD	SORBS1 →	+0.511	+0.019	.001	.001	3	6
OV	RPL10A →	-0.264	-0.024	<.001	.006	3	6
LUAD	RPL4 →	-0.242	-0.032	.005	<.001	3	6
COAD	S100A13 →	+0.452	+0.023	.001	.002	3	6
LUAD	HIP1 →	+0.271	+0.031	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007032 vs RPL5 — BRCA

Explore this scatter interactively →