Endosome organization

Across TCGA patient cohorts, RNA activity of the Endosome organization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCO1, TTC19, and ZNF180, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosome organization activity versus SCO1 in UCEC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCO1 →	-0.403	-0.180	.003	<.001	3	6
LUAD	TTC19 →	-0.430	-0.180	.001	.001	3	5
GBM	ZNF180 →	-0.500	-0.162	.002	.001	3	5
LUAD	NCBP3 →	-0.320	-0.168	.007	.006	3	5
GBM	C12orf45 →	-0.523	-0.186	.002	<.001	3	5
GBM	ZNF443 →	-0.487	-0.223	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007032 vs SCO1 — UCEC

Explore this scatter interactively →