Endosome organization

Across TCGA cell cohorts, RNA activity of the Endosome organization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDP1, HLA-E, and ARID3A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDP1 grouped by Endosome organization-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PDP1 →	+1.428	+0.284	.004	.002	3	5
LUNG_NSCLC_LUSC	HLA-E →	+2.115	+0.251	.003	<.001	3	5
LIVER	ARID3A →	-2.306	-0.252	<.001	.003	3	5
LIVER	ITGA3 →	+4.369	+0.279	<.001	<.001	3	5
LIVER	FGFR3 →	-3.988	-0.280	.002	.003	3	5
UPPER_AERODIGESTIVE_TRACT	SPAG1 →	+0.971	+0.184	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDP1 by Endosome organization activity — BREAST

Explore this box plot interactively →