Endosome organization

Across TCGA cell cohorts, RNA activity of the Endosome organization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSP90AB1, FARSB, and LRIG3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosome organization activity versus HSP90AB1 in PANCREAS (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HSP90AB1 →	+0.823	+1.294	.006	<.001	3	4
LIVER	FARSB →	+0.957	+0.280	.003	<.001	3	3
LIVER	LRIG3 →	-1.605	-0.202	<.001	.003	3	3
LIVER	VDAC1 →	+0.531	+0.225	.006	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	MAD2L1BP →	+0.640	+1.210	.003	.005	3	3
UPPER_AERODIGESTIVE_TRACT	ANAPC1 →	+1.123	+1.700	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007032 vs HSP90AB1 — PANCREAS

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