Peroxisome organization

Across TCGA patient cohorts, RNA activity of the Peroxisome organization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CKAP4_S26, DYNLL2, and TCEAL4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peroxisome organization activity versus CKAP4_S26 in LSCC (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CKAP4_S26 →	-0.581	-0.043	<.001	<.001	3	6
LSCC	DYNLL2 →	+0.353	+0.050	<.001	<.001	3	6
BRCA	TCEAL4 →	+0.416	+0.022	.001	.001	3	6
LSCC	CMBL →	+0.817	+0.039	<.001	.003	3	6
BRCA	FERMT3 →	-0.368	-0.030	.001	<.001	3	6
LSCC	HSPA13 →	-0.337	-0.031	.003	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007031 vs CKAP4_S26 — LSCC

Explore this scatter interactively →