Peroxisome organization

Across TCGA patient cohorts, RNA activity of the Peroxisome organization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THG1L, PHYHIP, and PODN, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peroxisome organization activity versus THG1L in UCEC (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	THG1L →	-0.644	-0.146	.006	.004	3	3
UCEC	PHYHIP →	-0.742	-0.210	<.001	<.001	3	3
UCEC	PODN →	-0.981	-0.167	<.001	<.001	3	3
UCEC	LAYN →	-0.750	-0.163	<.001	.001	3	3
UCEC	TMEM200B →	-0.960	-0.177	<.001	<.001	3	3
UCEC	MAOB →	-0.779	-0.135	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007031 vs THG1L — UCEC

Explore this scatter interactively →