Peroxisome organization

Across TCGA cell cohorts, RNA activity of the Peroxisome organization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEX3A, GPR153, and GNA12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MEX3A grouped by Peroxisome organization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MEX3A →	-1.815	-0.235	<.001	.004	3	4
SOFT_TISSUE	GPR153 →	-1.761	-0.423	.003	.004	3	3
OESOPHAGUS	GNA12 →	-0.828	-0.226	.002	<.001	3	3
BREAST	PLEKHO1 →	-2.212	-0.730	<.001	.004	3	3
BREAST	TOR1A →	-0.618	-0.382	<.001	.006	3	3
BREAST	NLGN4X →	-1.203	-0.504	.007	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MEX3A by Peroxisome organization activity — OESOPHAGUS

Explore this box plot interactively →