Golgi organization

Across TCGA patient cohorts, RNA activity of the Golgi organization pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTHRC1, MPRIP, and RPL11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi organization activity versus CTHRC1 in CCRCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CTHRC1 →	+0.713	+0.021	<.001	<.001	3	6
CCRCC	MPRIP →	+0.186	+0.019	.004	.002	3	6
LUAD	RPL11 →	-0.116	-0.026	.004	.004	3	5
GBM	DNM1 →	+0.481	+0.034	.001	<.001	3	5
LSCC	FAM83H_S870 →	-0.869	-0.032	<.001	<.001	3	5
HNSC	KIF1A_S1370 →	+1.403	+0.049	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007030 vs CTHRC1 — CCRCC

Explore this scatter interactively →