Golgi organization

Across TCGA cell cohorts, RNA activity of the Golgi organization pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED10, CDK1, and TMED2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMED10 grouped by Golgi organization-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TMED10 →	-0.179	-0.170	<.001	<.001	3	5
BLOOD_Leukemia	CDK1 →	-0.314	-0.198	.001	<.001	3	5
BLOOD_Myeloma	TMED2 →	-0.463	-0.213	.001	.006	3	4
CNS	RBP5 →	+0.196	+0.245	<.001	.002	3	4
LIVER	ADCY1 →	+0.207	+0.338	.003	.002	3	4
KIDNEY	TRAPPC8 →	-0.627	-0.339	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMED10 by Golgi organization activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →