Golgi organization

Across TCGA cell cohorts, RNA activity of the Golgi organization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLFN13, ATP5F1A, and H4C11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLFN13 grouped by Golgi organization-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SLFN13 →	+3.504	+0.252	<.001	<.001	3	5
SOFT_TISSUE	ATP5F1A →	-1.024	-0.286	.004	<.001	3	4
KIDNEY	H4C11 →	-1.775	-0.244	.003	.005	3	4
LIVER	ASRGL1 →	-1.881	-0.301	.001	.002	3	4
SKIN	PIGT →	+0.669	+0.208	.002	.006	3	4
LUNG_NSCLC_LUAD	CDRT1 →	+1.439	+0.184	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLFN13 by Golgi organization activity — STOMACH

Explore this box plot interactively →