Golgi organization

Across TCGA cell cohorts, RNA activity of the Golgi organization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MUC20, RABEP2, and TMEM125, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi organization activity versus MUC20 in OESOPHAGUS (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MUC20 →	+3.880	+0.196	<.001	<.001	3	5
LUNG_NSCLC_LUAD	RABEP2 →	+1.062	+0.196	<.001	<.001	3	5
OVARY	TMEM125 →	+4.382	+0.182	<.001	.003	3	5
BREAST	TSPAN1 →	+2.013	+0.115	.007	.008	3	5
LUNG_NSCLC_LUAD	ALDH3B2 →	+2.109	+0.154	<.001	.004	3	5
PANCREAS	BCAM →	+2.040	+0.142	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007030 vs MUC20 — OESOPHAGUS

Explore this scatter interactively →