Cytoplasm organization

Across TCGA patient cohorts, RNA activity of the Cytoplasm organization pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CELF1, TDRKH, and ARHGAP31_S1432, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoplasm organization activity versus CELF1 in PDAC (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CELF1 →	+0.246	+0.070	.001	.001	3	5
BRCA	TDRKH →	+0.362	+0.061	<.001	<.001	3	4
HNSC	ARHGAP31_S1432 →	-0.480	-0.072	<.001	.001	3	4
BRCA	HEATR1 →	+0.289	+0.041	<.001	<.001	3	4
BRCA	SLC4A1AP →	+0.282	+0.040	<.001	.001	3	4
PDAC	DCLK2_S362 →	-0.356	-0.063	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007028 vs CELF1 — PDAC

Explore this scatter interactively →