Cytoplasm organization

Across TCGA patient cohorts, RNA activity of the Cytoplasm organization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF720, DENND1A, and TAS2R14, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoplasm organization activity versus ZNF720 in OV (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZNF720 →	+0.346	+0.508	.001	.002	3	3
LUAD	DENND1A →	+0.281	+0.397	.002	.005	3	3
PDAC	TAS2R14 →	+0.408	+0.938	.003	<.001	3	3
PDAC	ASAP1-IT2 →	+0.341	+0.590	.001	.004	3	3
PDAC	PDCD7 →	+0.184	+0.545	.001	.001	3	3
UCEC	MAPT →	-0.512	-0.626	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007028 vs ZNF720 — OV

Explore this scatter interactively →