Cytoplasm organization

Across TCGA cell cohorts, RNA activity of the Cytoplasm organization pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRN3, NAGLU, and SOS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RRN3 grouped by Cytoplasm organization-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RRN3 →	-0.229	-0.507	<.001	.006	3	9
CNS	NAGLU →	-0.282	-1.429	<.001	<.001	3	8
BLOOD_Leukemia	SOS1 →	-0.541	-0.847	.001	.003	3	8
CNS	PRPF6 →	-0.301	-0.941	.003	.002	3	4
OESOPHAGUS	MTM1 →	+0.220	+0.402	.004	.004	3	4
OESOPHAGUS	OR2L5 →	-0.159	-0.499	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RRN3 by Cytoplasm organization activity — LARGE_INTESTINE

Explore this box plot interactively →