Cytoplasm organization

Across TCGA cell cohorts, RNA activity of the Cytoplasm organization pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTBD19, TRAM1L1, and TES, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoplasm organization activity versus BTBD19 in SKIN (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BTBD19 →	+1.975	+1.578	.002	<.001	3	2
LARGE_INTESTINE	TRAM1L1 →	+0.916	+1.710	.001	<.001	3	2
BREAST	TES →	-1.789	-1.608	<.001	.001	2	2
BREAST	CPSF4 →	-0.808	-1.608	.001	.001	2	2
SKIN	RHBDD3 →	+0.546	+0.957	<.001	.009	3	1
SKIN	GZMB →	+0.494	+1.705	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007028 vs BTBD19 — SKIN

Explore this scatter interactively →