Post-chaperonin tubulin folding pathway

Across TCGA patient cohorts, RNA activity of the Post-chaperonin tubulin folding pathway pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, TBCEL, and TNS2_S120, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Post-chaperonin tubulin folding pathway activity versus RSU1 in COAD (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RSU1 →	+0.416	+0.032	.005	<.001	3	7
OV	TBCEL →	+0.407	+0.042	.001	.001	2	8
LSCC	TNS2_S120 →	+0.584	+0.080	<.001	<.001	3	7
BRCA	UTRN →	+0.324	+0.029	<.001	.008	3	7
CCRCC	OLFML1 →	+0.932	+0.044	<.001	<.001	3	7
CCRCC	PDLIM7 →	+0.655	+0.044	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007023 vs RSU1 — COAD

Explore this scatter interactively →