Post-chaperonin tubulin folding pathway

Across TCGA patient cohorts, RNA activity of the Post-chaperonin tubulin folding pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGFR, N4BP2L1, and UTS2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Post-chaperonin tubulin folding pathway activity versus PTGFR in UCEC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTGFR →	+0.754	+0.091	.001	.001	3	4
BRCA	N4BP2L1 →	+0.446	+0.136	.005	<.001	3	4
OV	UTS2B →	+0.135	+0.103	.009	.005	3	4
LSCC	TBCEL →	+0.423	+0.120	<.001	.002	3	4
BRCA	TXLNB →	+0.495	+0.128	.009	.002	3	3
UCEC	LRRN4CL →	+0.757	+0.130	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007023 vs PTGFR — UCEC

Explore this scatter interactively →