Tubulin complex assembly

Across TCGA patient cohorts, RNA activity of the Tubulin complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBCEL, CRYAB, and CACNA2D1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tubulin complex assembly activity versus TBCEL in OV (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TBCEL →	+0.413	+0.051	.001	<.001	3	8
HNSC	CRYAB →	+0.946	+0.065	<.001	.002	3	7
HNSC	CACNA2D1 →	+0.816	+0.059	<.001	.001	3	6
PDAC	EHD3 →	+0.387	+0.059	.003	<.001	3	6
COAD	CALD1_S493 →	+0.646	+0.042	<.001	<.001	3	6
PDAC	KIAA1522 →	-0.249	-0.041	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007021 vs TBCEL — OV

Explore this scatter interactively →