Tubulin complex assembly

Across TCGA cell cohorts, RNA activity of the Tubulin complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYZ, SHC2, and RAB40B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LYZ grouped by Tubulin complex assembly-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LYZ →	-4.923	-0.249	.008	.006	3	5
LUNG_SCLC	SHC2 →	-2.677	-0.308	.004	.005	3	4
LUNG_SCLC	RAB40B →	-1.655	-0.269	<.001	.004	3	4
LUNG_SCLC	PDGFC →	+2.610	+0.276	.004	.001	3	4
LUNG_SCLC	ROGDI →	-1.111	-0.377	.002	.008	2	5
LUNG_SCLC	NSF →	-0.636	-0.266	.002	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LYZ by Tubulin complex assembly activity — BLOOD_Leukemia

Explore this box plot interactively →