Tubulin complex assembly

Across TCGA cell cohorts, RNA activity of the Tubulin complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DGUOK, POLR1E, and UTP18, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tubulin complex assembly activity versus DGUOK in LUNG_NSCLC_LUSC (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DGUOK →	+0.877	+0.469	.009	.006	3	7
PANCREAS	POLR1E →	+1.191	+0.344	<.001	<.001	3	7
OVARY	UTP18 →	+0.759	+0.314	<.001	<.001	3	7
BLOOD_Leukemia	SGO1 →	+1.025	+0.191	<.001	.005	3	6
URINARY_TRACT	PRPS1 →	+2.014	+0.546	.002	.007	2	7
LUNG_NSCLC_LUSC	COL17A1 →	-6.640	-0.463	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007021 vs DGUOK — LUNG_NSCLC_LUSC

Explore this scatter interactively →