Microtubule depolymerization

Across TCGA cell cohorts, RNA activity of the Microtubule depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CKAP5, KCTD9, and PLCB4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CKAP5 grouped by Microtubule depolymerization-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CKAP5 →	-0.827	-0.246	<.001	.003	3	5
LARGE_INTESTINE	KCTD9 →	-0.885	-0.236	.005	.007	3	4
UPPER_AERODIGESTIVE_TRACT	PLCB4 →	-1.000	-0.283	.006	.008	2	5
BLOOD_Lymphoma	FAM216A →	-0.972	-0.338	<.001	.001	3	4
LUNG_NSCLC_LUSC	MLKL →	+1.931	+0.302	.005	.006	3	4
LUNG_NSCLC_LUSC	ADAP1 →	+2.918	+0.343	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CKAP5 by Microtubule depolymerization activity — LARGE_INTESTINE

Explore this box plot interactively →