Microtubule depolymerization

Across TCGA cell cohorts, RNA activity of the Microtubule depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OVOL1, CENPS, and UHRF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule depolymerization activity versus OVOL1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	OVOL1 →	-0.924	-1.213	.001	.001	2	6
LARGE_INTESTINE	CENPS →	+0.578	+0.786	.001	<.001	3	5
OVARY	UHRF1 →	+1.424	+0.761	<.001	.006	3	5
PANCREAS	CAMLG →	+0.837	+0.424	.002	.009	3	5
PANCREAS	NAP1L1 →	+0.892	+0.291	.001	.003	3	5
URINARY_TRACT	ZNF428 →	+2.202	+2.157	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007019 vs OVOL1 — UPPER_AERODIGESTIVE_TRACT

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