Plasma membrane organization

Across TCGA patient cohorts, RNA activity of the Plasma membrane organization pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS1, TMEM119, and TPM1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane organization activity versus SORBS1 in COAD (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SORBS1 →	+0.634	+0.022	.002	.002	3	8
GBM	TMEM119 →	+0.794	+0.049	<.001	<.001	3	8
OV	TPM1 →	+0.631	+0.029	.001	<.001	3	8
LUAD	UTP14A →	-0.357	-0.024	<.001	.005	3	8
UCEC	CAVIN1 →	+0.588	+0.041	.008	.003	3	8
OV	EHD2 →	+0.850	+0.031	.003	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007009 vs SORBS1 — COAD

Explore this scatter interactively →