Plasma membrane organization

Across TCGA cell cohorts, RNA activity of the Plasma membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRFIP2, RCL1, and COTL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane organization activity versus LRRFIP2 in CNS (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LRRFIP2 →	+0.726	+0.152	.007	.008	3	5
KIDNEY	RCL1 →	-1.437	-0.216	.008	.007	2	6
URINARY_TRACT	COTL1 →	+1.559	+0.150	<.001	.001	3	5
OESOPHAGUS	ZNF280C →	-0.557	-0.194	<.001	<.001	3	5
CNS	PPP4R1 →	+0.802	+0.209	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SEC13 →	+0.501	+0.156	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007009 vs LRRFIP2 — CNS

Explore this scatter interactively →