Outer mitochondrial membrane organization

Across TCGA cell cohorts, RNA activity of the Outer mitochondrial membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAPBP, TGFBI, and AKTIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAPBP grouped by Outer mitochondrial membrane organization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TAPBP →	-1.529	-0.372	.001	.002	3	5
CNS	TGFBI →	-3.877	-0.538	<.001	.006	3	4
BREAST	AKTIP →	+0.729	+0.174	.009	.005	3	4
OESOPHAGUS	ACSL5 →	-3.187	-0.388	.006	.001	3	4
BREAST	LTB4R2 →	+1.166	+0.279	<.001	<.001	3	4
BREAST	DECR2 →	+0.944	+0.254	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAPBP by Outer mitochondrial membrane organization activity — PANCREAS

Explore this box plot interactively →