Outer mitochondrial membrane organization

Across TCGA cell cohorts, RNA activity of the Outer mitochondrial membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASB3, BBS7, and ARRDC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Outer mitochondrial membrane organization activity versus ASB3 in LARGE_INTESTINE (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASB3 →	-0.659	-0.212	.002	.004	3	4
LUNG_SCLC	BBS7 →	-0.882	-0.273	<.001	<.001	3	4
KIDNEY	ARRDC1 →	+1.027	+0.242	.001	.005	3	4
OVARY	EPCAM →	+4.553	+0.320	<.001	.001	3	4
BREAST	SEMA3B →	+1.803	+0.331	.006	<.001	3	4
LIVER	MIGA2 →	+0.544	+0.337	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007008 vs ASB3 — LARGE_INTESTINE

Explore this scatter interactively →