Inner mitochondrial membrane organization

Across TCGA patient cohorts, RNA activity of the Inner mitochondrial membrane organization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCML2_S511, RUVBL1, and RUVBL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner mitochondrial membrane organization activity versus SCML2_S511 in LSCC (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SCML2_S511 →	+0.906	+0.041	<.001	<.001	3	5
LSCC	RUVBL1 →	+0.212	+0.046	<.001	<.001	3	5
LSCC	RUVBL2 →	+0.215	+0.048	<.001	<.001	3	5
LSCC	SFPQ →	+0.214	+0.056	<.001	<.001	3	5
LSCC	TACO1 →	+0.497	+0.041	<.001	<.001	3	5
HNSC	TNIP2 →	-0.232	-0.060	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007007 vs SCML2_S511 — LSCC

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