Inner mitochondrial membrane organization

Across TCGA cell cohorts, RNA activity of the Inner mitochondrial membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGCT, FOXL1, and SNRNP70, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GGCT grouped by Inner mitochondrial membrane organization-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GGCT →	+1.045	+0.191	<.001	.003	3	5
BONE	FOXL1 →	-2.627	-0.273	.006	.009	3	4
LIVER	SNRNP70 →	+0.686	+0.219	<.001	.003	3	4
BREAST	EHMT1 →	+0.736	+0.164	<.001	.003	3	4
SOFT_TISSUE	PMPCA →	+0.882	+0.437	<.001	.003	3	4
SOFT_TISSUE	LPAR1 →	-3.460	-0.260	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GGCT by Inner mitochondrial membrane organization activity — BREAST

Explore this box plot interactively →