Inner mitochondrial membrane organization

Across TCGA cell cohorts, RNA activity of the Inner mitochondrial membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OGT, SYNE3, and PRRC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner mitochondrial membrane organization activity versus OGT in SKIN (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OGT →	+0.820	+0.240	<.001	.004	3	5
LUNG_SCLC	SYNE3 →	-1.617	-0.211	<.001	<.001	3	4
URINARY_TRACT	PRRC1 →	-0.553	-0.338	.005	.008	3	4
BLOOD_Myeloma	SLC35A2 →	+0.793	+0.230	.003	.004	3	4
OESOPHAGUS	TAF1 →	+1.222	+0.296	.005	.001	3	4
LUNG_NSCLC_LUAD	NPRL3 →	+0.632	+0.253	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007007 vs OGT — SKIN

Explore this scatter interactively →