Mitochondrial membrane organization

Across TCGA patient cohorts, RNA activity of the Mitochondrial membrane organization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TDRKH, ARHGAP27, and RPL28, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial membrane organization activity versus TDRKH in LSCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TDRKH →	+0.302	+0.020	<.001	.003	3	5
PDAC	ARHGAP27 →	-0.170	-0.015	.005	.001	2	5
GBM	RPL28 →	-0.374	-0.027	<.001	<.001	3	4
GBM	RPS13 →	-0.281	-0.037	<.001	<.001	3	4
HNSC	SPAG9_S730 →	-0.245	-0.057	.001	<.001	3	4
LUAD	STMN1 →	+0.456	+0.024	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007006 vs TDRKH — LSCC

Explore this scatter interactively →