Mitochondrial membrane organization

Across TCGA patient cohorts, RNA activity of the Mitochondrial membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOT1, UBXN6, and FBXO5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial membrane organization activity versus GOT1 in HNSC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GOT1 →	+1.164	+0.152	.001	<.001	3	4
CCRCC	UBXN6 →	+0.329	+0.206	.001	<.001	3	4
UCEC	FBXO5 →	-0.708	-0.177	.001	.005	3	4
GBM	DNAJB2 →	+0.234	+0.096	.002	.005	3	4
OV	NAALADL1 →	-0.652	-0.161	.002	.001	3	4
UCEC	VRK1 →	-0.588	-0.225	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007006 vs GOT1 — HNSC

Explore this scatter interactively →