Mitochondrial membrane organization

Across TCGA cell cohorts, RNA activity of the Mitochondrial membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC5A6, TCEAL3, and CASP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC5A6 grouped by Mitochondrial membrane organization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC5A6 →	+0.991	+0.344	.001	<.001	3	5
SOFT_TISSUE	TCEAL3 →	-1.934	-0.335	.002	.001	2	6
LARGE_INTESTINE	CASP1 →	-2.283	-0.341	<.001	<.001	3	5
SOFT_TISSUE	EHHADH →	-1.638	-0.347	.001	.002	3	4
SOFT_TISSUE	PDLIM4 →	-3.024	-0.227	.005	.009	2	5
SOFT_TISSUE	ZNF785 →	-2.350	-0.265	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC5A6 by Mitochondrial membrane organization activity — SOFT_TISSUE

Explore this box plot interactively →