Nucleolus organization

Across TCGA patient cohorts, RNA activity of the Nucleolus organization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC1A, ADNP, and CHD4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleolus organization activity versus SMC1A in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC1A →	+0.345	+0.052	<.001	<.001	3	7
HNSC	ADNP →	+0.365	+0.084	<.001	<.001	3	7
GBM	CHD4 →	+0.382	+0.041	<.001	.001	3	7
HNSC	GTF3C2 →	+0.319	+0.081	<.001	<.001	3	7
GBM	SMARCC2 →	+0.276	+0.050	<.001	<.001	3	7
GBM	WEE1_T190 →	+0.878	+0.047	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007000 vs SMC1A — GBM

Explore this scatter interactively →