Nucleolus organization

Across TCGA patient cohorts, RNA activity of the Nucleolus organization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC25A, RAD51AP1, and TTK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleolus organization activity versus CDC25A in GBM (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CDC25A →	+0.749	+0.911	.005	<.001	3	6
LSCC	RAD51AP1 →	+0.921	+0.725	<.001	<.001	3	5
LSCC	TTK →	+0.862	+0.915	.001	<.001	3	5
BRCA	NCAPH →	+0.686	+0.647	.001	<.001	3	5
LSCC	KIF18A →	+0.738	+0.790	.001	<.001	3	5
LSCC	AUNIP →	+0.790	+0.682	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007000 vs CDC25A — GBM

Explore this scatter interactively →