Nucleolus organization

Across TCGA patient cohorts, RNA activity of the Nucleolus organization pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX18, PHIP, and SF3B1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleolus organization activity versus DDX18 in COAD (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DDX18 →	+0.302	+0.926	<.001	<.001	3	6
LSCC	PHIP →	+0.348	+0.847	<.001	<.001	3	5
BRCA	SF3B1 →	+0.226	+0.925	<.001	<.001	3	5
BRCA	TOP1 →	+0.334	+0.683	<.001	<.001	3	5
LUAD	PDS5A_S1305 →	+0.481	+0.648	.001	<.001	3	5
BRCA	SMARCA5 →	+0.375	+0.871	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007000 vs DDX18 — COAD

Explore this scatter interactively →