Nuclear pore organization

Across TCGA patient cohorts, RNA activity of the Nuclear pore organization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNMT, HAT1, and CDC20_T70, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear pore organization activity versus RNMT in LUAD (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNMT →	+0.392	+0.068	<.001	<.001	3	9
LSCC	HAT1 →	+0.507	+0.093	<.001	<.001	3	9
GBM	CDC20_T70 →	+1.029	+0.071	<.001	.002	3	8
GBM	SMC2 →	+0.940	+0.080	<.001	<.001	3	8
HNSC	MCM2 →	+0.468	+0.091	<.001	<.001	3	8
GBM	MCM4 →	+0.815	+0.060	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006999 vs RNMT — LUAD

Explore this scatter interactively →