Nuclear pore organization

Across TCGA patient cohorts, RNA activity of the Nuclear pore organization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIP13, HMMR, and CENPI, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear pore organization activity versus TRIP13 in LSCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRIP13 →	+0.873	+0.734	<.001	.002	3	8
BRCA	HMMR →	+0.947	+0.784	<.001	.001	3	8
LSCC	CENPI →	+0.685	+0.916	<.001	<.001	3	7
HNSC	NCAPD2 →	+0.883	+0.610	<.001	<.001	3	7
BRCA	FOXM1 →	+1.211	+0.883	<.001	<.001	3	7
BRCA	TTK →	+1.249	+0.976	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006999 vs TRIP13 — LSCC

Explore this scatter interactively →