Nuclear pore organization

Across TCGA cell cohorts, RNA activity of the Nuclear pore organization pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCR2, CDX4, and GRM3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCR2 grouped by Nuclear pore organization-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CCR2 →	-0.197	-0.229	<.001	<.001	3	5
BLOOD_Lymphoma	CDX4 →	-0.292	-0.360	.002	.001	3	5
CNS	GRM3 →	+0.423	+0.256	<.001	<.001	3	5
CNS	BIRC3 →	+0.118	+0.130	.008	.004	3	5
BREAST	NUP54 →	-0.342	-0.147	<.001	<.001	3	4
BONE	CA12 →	-0.215	-0.166	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCR2 by Nuclear pore organization activity — OVARY

Explore this box plot interactively →