Nuclear pore organization

Across TCGA cell cohorts, RNA activity of the Nuclear pore organization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBLB, USP20, and SAMD10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CBLB grouped by Nuclear pore organization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CBLB →	+0.940	+0.184	.002	<.001	3	4
PANCREAS	USP20 →	+0.891	+0.137	<.001	<.001	3	4
BLOOD_Lymphoma	SAMD10 →	+1.023	+0.305	.006	.001	3	4
STOMACH	B3GLCT →	-0.883	-0.195	.005	.001	3	4
PANCREAS	COTL1 →	-0.872	-0.161	.004	<.001	3	3
OESOPHAGUS	CYP1A1 →	+2.245	+0.163	.006	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CBLB by Nuclear pore organization activity — PANCREAS

Explore this box plot interactively →