Nuclear pore organization

Across TCGA cell cohorts, RNA activity of the Nuclear pore organization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIB1, SKP2, and MGLL, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear pore organization activity versus CIB1 in LARGE_INTESTINE (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CIB1 →	-0.588	-0.193	.001	.003	3	7
OVARY	SKP2 →	+1.256	+0.200	.007	.007	3	7
BREAST	MGLL →	-1.858	-0.262	.001	<.001	3	7
OVARY	HPCAL1 →	-1.675	-0.224	<.001	.002	3	5
STOMACH	SCP2 →	-0.968	-0.272	.003	.002	3	5
OVARY	VASH2 →	+1.429	+0.245	.004	.004	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006999 vs CIB1 — LARGE_INTESTINE

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