Nuclear envelope organization

Across TCGA patient cohorts, RNA activity of the Nuclear envelope organization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are INPP4A, AKT3, and HDAC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear envelope organization activity versus INPP4A in BRCA (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	INPP4A →	+0.177	+0.034	<.001	<.001	3	6
OV	AKT3 →	+0.662	+0.039	.008	<.001	3	6
HNSC	HDAC2 →	+0.216	+0.047	<.001	.005	3	6
LUAD	RECQL →	+0.360	+0.024	<.001	.002	3	5
GBM	EPS8L2 →	-0.638	-0.051	<.001	.001	3	5
LUAD	HOOK2 →	-0.240	-0.027	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006998 vs INPP4A — BRCA

Explore this scatter interactively →