Nuclear envelope organization

Across TCGA patient cohorts, RNA activity of the Nuclear envelope organization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C8orf34-AS1, SBDS, and CHST3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear envelope organization activity versus C8orf34-AS1 in UCEC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C8orf34-AS1 →	-1.085	-0.143	<.001	.001	3	4
LUAD	SBDS →	+0.495	+0.185	<.001	<.001	3	4
GBM	CHST3 →	+0.484	+0.161	.002	.003	3	3
GBM	MAP3K3 →	+0.340	+0.168	<.001	<.001	3	3
LUAD	KIF1A →	-1.617	-0.149	<.001	.006	3	3
UCEC	GGT5 →	+0.484	+0.121	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006998 vs C8orf34-AS1 — UCEC

Explore this scatter interactively →