Nucleus organization

Across TCGA patient cohorts, RNA activity of the Nucleus organization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLTB, SMC3, and SMC5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleus organization activity versus CLTB in HNSC (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLTB →	-0.410	-0.059	<.001	.003	3	6
HNSC	SMC3 →	+0.267	+0.063	<.001	.004	3	6
BRCA	SMC5 →	+0.299	+0.031	<.001	<.001	3	6
LSCC	UCHL1 →	+0.868	+0.026	.003	.006	2	7
BRCA	HDAC2 →	+0.404	+0.035	<.001	<.001	3	6
BRCA	MCM2 →	+0.619	+0.023	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006997 vs CLTB — HNSC

Explore this scatter interactively →