Nucleus organization

Across TCGA cell cohorts, RNA activity of the Nucleus organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFSD2A, ADPRM, and UCP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MFSD2A grouped by Nucleus organization-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MFSD2A →	+2.106	+0.185	.004	.001	3	5
BLOOD_Leukemia	ADPRM →	-0.962	-0.179	<.001	<.001	3	4
BONE	UCP3 →	+0.858	+0.161	.008	.003	3	4
LIVER	KIF3B →	+0.837	+0.188	.007	.006	3	4
LUNG_NSCLC_LUAD	PPP3R1 →	-0.376	-0.141	.003	.002	3	3
BLOOD_Leukemia	NCAPD2 →	-0.589	-0.150	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MFSD2A by Nucleus organization activity — BLOOD_Lymphoma

Explore this box plot interactively →