Nucleus organization

Across TCGA cell cohorts, RNA activity of the Nucleus organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PANX1, HS6ST2, and ZNF175, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleus organization activity versus PANX1 in BLOOD_Lymphoma (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PANX1 →	+1.354	+0.199	<.001	<.001	3	6
OVARY	HS6ST2 →	+1.752	+0.135	<.001	.003	3	5
BLOOD_Myeloma	ZNF175 →	+1.443	+0.125	.004	.002	3	5
LUNG_SCLC	CEP170 →	+1.186	+0.134	.001	<.001	3	5
LUNG_SCLC	SART1 →	+0.444	+0.099	.005	.006	3	5
KIDNEY	RNMT →	+1.259	+0.287	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006997 vs PANX1 — BLOOD_Lymphoma

Explore this scatter interactively →